Dr Anita Grigoriadis
Lecturer in Cancer Bioinformatics
Anita Grigoriadis leads the Cancer Bioinformatics group, and is the Training Lead for the CRUK KHP Centre at King’s College London (KCL) and a lecturer at Birkbeck, University of London. After her Master’s degree at the Institute of Molecular Pathology, University of Vienna (Austria), she received her PhD at the Ludwig Institute for Cancer Research (LICR), London UK. Anita conducted her postdoctoral training on breast cancer genomics as a bioinformatician at the LICR, and later moved to the Breakthrough Breast Cancer Centre (London) with Professor Alan Ashworth. In 2008, she joined the Breast Cancer NOW Unit (formerly Breakthrough Breast Cancer Research) at KCL under the leadership of Professor Andrew Tutt, where her bioinformatics interest in studying genomic instability and immune-related features in breast cancer started.
Having joined the group in 2013, Hasan is a keen Scientific Programmer funded by Breast Cancer Now. His multi-project translational research focuses on cross-omics data biomarker identification and validation in triple-negative breast cancers. Recently, he has conducted rigorous analyses on various markers for genomic instability and transcriptional aberrations using data from human samples, mouse models, and patient-derived Xenografts. His current work focuses on a deeper understanding of the cancer immune microenvironment and its interaction with various omic markers.
Hasan is responsible for managing the high performance computing (HPC) and storage requirements across the Innovation Hub at the New Guys Cancer Centre. He works closely with collaborators at King’s College London, the Institute of Cancer Research (ICR), and the Crick Institute and has actively maintained and upgraded the high-throughput data mining server TARGETID.
Jelmar Quist received his undergraduate degree in Bioinformatics from the University of Applied Sciences Leiden, The Netherlands, followed by a one-year Master of Research in Bioinformatics with Systems Biology at Birkbeck, University of London. In 2013 he obtained a PhD studentship in Translational Medicine from the NIHR Biomedical Research Centre at Guy’s and St Thomas’. As part of this studentship he acquired a Master of Research in Biomedical and Translational Research. He is currently a final year PhD student in the Cancer Bioinformatics team. His work focuses on the transcriptomic and genomic landscape of triple-negative breast cancers with regards to subtyping, genomic instability, and drivers of genomic instability. In particular, he has a keen interest in genomic scars, defined as characteristic imprints on the genome as a result of the ectopic expression of HORMAD1, a novel driver of genomic instability in TNBC (Watkins et al. Cancer Discov. 2015). His work on novel TNBC subtyping was selected for an oral presentation at ASCO 2017.
Dalia Tarantino received her undergraduate degree in Human Genetics at the University of Leeds. This included a year studying abroad at the Faculté Libre de Sciences et Technologies, University of Lille, France. After completing a Master of Research in Translational Medicine at the University of Manchester, she obtained a research scientist position at AstraZeneca R&D, Oncology iMED, Alderley Park, where she focused on the development of immunohistochemistry-based assays for target validation and patient selection during clinical trials. In 2013 she was offered a 1+3 (MRes + PhD) studentship from the NIHR Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust, as part of which she obtained an MRes in Translational and Biomedical Science. Dalia is now a third-year PhD student in the Cancer Bioinformatics team. Her research centres on the experimental validation of genomic scars arising from specific DNA repair deficiencies in triple-negative breast cancer. In her spare time, Dalia volunteers for the National Trust and has participated in different pop-up projects, including walking tours of the Balfron Tower in London.
Trained as a Bioinformatician Salpie Nowinski is experienced in omics data analysis. Having received her undergraduate degree from Edinburgh University (BSc, Hons), an MSc in Bioinformatics from Birkbeck (MSc, Hons), she then worked as a bioinformatician for two years in Breast Cancer Genetics group at King’s College London with Professor Elinor Sawyer.
Funded by Prostate Cancer UK, Salpie is currently in her final year as a PhD candidate at the Cancer Bioinformatics team. Her work focuses on identifying molecular markers that predict which men with low-grade prostate cancer and who are on active surveillance, require immediate intervention. Her novel approach combines both germline and somatic markers identified by interrogating SNP-based array and low pass whole-genome-sequencing data from both publicly available databases and biopsy tissues acquired from the King’s Health Partners Biobank. During her 2nd PhD year she visited the Loda Lab at Harvard University (USA) through a grant awarded by KCL. Salpie also presented her work at the Royal College of Physicians in 2016. Her interests include artificial intelligence techniques (e.g. machine learning and neural networks), personalised medicine, and reading.
Orsolya completed her doctoral studies in the Cell Biophysics research group at the Biological Research Centre of the Hungarian Academy of Sciences. After receiving her PhD she worked for the Anthony Nolan Trust, a charity supporting stem cell transplant research, then she joined the Clinical Trials and Statistics Unit of The Institute of Cancer Research (ICR). In September 2017 Orsolya moved to the Bioinformatics Team in the Breast Cancer Now Centre at ICR in collaboration with our group. She is currently working on the data analysis of the Triple Negative breast cancer Trial (TNT) focusing on potential molecular biomarkers. Her main research interests are analysis of integrated multi-omics datasets and applications of machine learning technology in clinical trials.
Tom completed his undergraduate degree in Biochemistry from King’s College London. This was followed by a Master of Science in Bioinformatics and Theoretical Systems Biology from Imperial College London. He Joined the group in October 2017 as an MRC funded PhD student working on lymph node expression data.
Dr. Gaurav Chatterjee is a trained Hematopathologist and Clinical Flowcytometrist at Tata Memorial Hospital, Mumbai, India. Currently he is pursuing his Master in Research in Translational Cancer Medicine at King’s College London. His project in the group include exploring changes in gene expression in pre-metastatic lymph node in mouse model.
Summer Research Student
Max is a Biochemistry Undergraduate from King’s College London undertaking a summer studentship at the Breast Cancer Research Unit. He received the prestigious BBSRC studentship of which only one per year is allocated to KCL. He is investigating the transcriptional regulation mechanisms of the genomic instability driver HORMAD1, by interrogating methylation, WGS, ENCODE, and gene expression data.