Publications – Anita Grigoriadis Group

2024

Natural history of germline BRCA1 mutated and BRCA wild-type triple-negative breast cancer. Laxman Gardi N, Chaubal R, Parab P, Pachakar S, Sureshchandra Kulkarni S, Shet K, Joshi S, Kembhavi Y, Chandrani P, Quist J, Kowtal P, Grigoriadis A, Sarin A, Govindrajan R, Gupta S. Cancer Research Communications. 2024. doi:10.1158/2767-9764.CRC-23-0277

2023

Leveraging circulating microbial DNA for early cancer detection. Kataria R, Shoaie S, Grigoriadis A, Wan JCM.
Trends Cancer. 2023 Nov;9(11):879-882. doi: 10.1016/j.trecan.2023.08.001. Epub 2023 Sep 1. PMID: 37659908
Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers. Lau HSH, Tan VKM, Tan BKT, Sim Y, Quist J, Thike AA, Tan PH, Pervaiz S, Grigoriadis A, Sabapathy K. NPJ Breast Cancer. 2023 Oct 20;9(1):84. doi: 10.1038/s41523-023-00590-7. PMID: 37863888
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects.Verghese G, Lennerz JK, Ruta D, Ng W, Thavaraj S, Siziopikou KP, Naidoo T, Rane S, Salgado R, Pinder SE, Grigoriadis A. J Pathol. 2023 Aug;260(5):551-563. doi: 10.1002/path.6163. Epub 2023 Aug 14. PMID: 37580849 Review.
Spatial analyses of immune cell infiltration in cancer: current methods and future directions: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Page DB, Broeckx G, Jahangir CA, International Immuno-Oncology Biomarker Working Group on Breast Cancer. J Pathol. 2023 Aug;260(5):514-532. doi: 10.1002/path.6165. Epub 2023 Aug 23. PMID: 37608771
Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Thagaard J, Broeckx G, Page DB, International Immuno-Oncology Biomarker Working Group on Breast Cancer. J Pathol. 2023 Aug;260(5):498-513. doi: 10.1002/path.6155. Epub 2023 Aug 23. PMID: 37608772; PMCID: PMC10518802.
B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma.Crescioli S, Correa I, Ng J, Willsmore ZN, Laddach R, Chenoweth A, Chauhan J, Di Meo A, Stewart A, Kalliolia E, Alberts E, Adams R, Harris RJ, Mele S, Pellizzari G, Black ABM, Bax HJ, Cheung A, Nakamura M, Hoffmann RM, Terranova-Barberio M, Ali N, Batruch I, Soosaipillai A, Prassas I, Ulndreaj A, Chatanaka MK, Nuamah R, Kannambath S, Dhami P, Geh JLC, MacKenzie Ross AD, Healy C, Grigoriadis A, Kipling D, Karagiannis P, Dunn-Walters DK, Diamandis EP, Tsoka S, Spicer J, Lacy KE, Fraternali F, Karagiannis SN. Nat Commun. 2023 Jun 8;14(1):3378. doi: 10.1038/s41467-023-39042-y. PMID: 37291228
Multiscale deep learning framework captures systemic immune features in lymph nodes predictive of triple negative breast cancer outcome in large-scale studies. Verghese G, Li M, Liu F, Lohan A, Kurian NC, Meena S, Gazinska P, Shah A, Oozeer A, Chan T, Opdam M, Linn S, Gillett C, Alberts E, Hardiman T, Jones S, Thavaraj S, Jones JL, Salgado R, Pinder SE, Rane S, Sethi A, Grigoriadis A. J Pathol. 2023 May 25. doi: 10.1002/path.6088 PMID: 37230111
B Cells in Breast Cancer Pathology. Li M, Quintana A, Alberts E, Hung MS, Boulat V, Ripoll MM, Grigoriadis A. B Cells in Breast Cancer Pathology. Cancers. 2023; 15(5):1517. https://doi.org/10.3390/cancers15051517

2022

CDK Inhibition Primes for Anti-PD-L1 Treatment in Triple-Negative Breast Cancer Models. Cheung A, Chenoweth AM, Quist J, Sow HS, Malaktou C, Ferro R, Hoffmann RM, Osborn G, Sachouli E, French E, Marlow R, Lacy KE, Papa S, Grigoriadis A, Karagiannis SN. Cancers (Basel). 2022 Jul 11;14(14):3361. doi: 10.3390/cancers14143361. PMID: 35884422
Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood. Isobelle Wall, Victoire Boulat, Aekta Shah, Kim R. M. Blenman, Yin Wu, Elena Alberts, Dinis Pedro Calado, Roberto Salgado, and Anita Grigoriadis. 2022. Cancers 14, no. 18: 4505. https://doi.org/10.3390/cancers14184505.
Deep Multi-Scale U-Net Architecture and Label-Noise Robust Training Strategies for Histopathological Image Segmentation. Kurian NC, Lohan A, Verghese G, Dharamshi N, Meena S, Li M, Liu F, Gillet C, Rane S, Grigoriadis A, Seth A. Conference on Bioinformatics and Bioengineering (BIBE), Taichung, Taiwan, 2022, pp. 91-96, doi: 10.1109/BIBE55377.2022.00027.
Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance. Tarantino D, Walker C, Weekes D, Pemberton D, Davidson K, Frankum J, Mendes-Pereira A, Prince C, Ferro R, Brough R, Pettitt S, Lord C, Grigoriadis A, Tutt A. Oncogene. 2022 Jun 29. doi: 10.1038/s41388-022-02369-9. PMID: 35768547.
Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC. Harrasser M, Gohil SH, Lau H, Della Peruta M, Muczynski V, Patel D, Miranda E, Grigoriadis K, Grigoriadis A, Granger D, Evans R, Nathwani A. Breast Cancer Res. 2022 Jun 3;24(1):39. doi: 10.1186/s13058-022-01531-1.PMID: 35659040.
Clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancers defined by genomic analysis. Lips E, Kumar T, Megalios A, Visser L, Sheinman M, Fortunato A, Shah V, Hoogstraat M, Sei E, Mallo D, Roman-Escorza M, Ahmed A, …Grigoriadis A, … Sawyer EJ, on behalf of the Grand Challenge PRECISION consortium. Nat Genet. 2022 Jun;54(6):850-860. doi: 10.1038/s41588-022-01082-3. Epub 2022 Jun 9. PMID: 35681052.

2021

TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer. Beatson RE, Parente-Pereira AC, Halim L, Cozzetto D, Hull C, Whilding LM, Martinez O, Taylor CA, Obajdin J, Luu Hoang KN, Draper B, Iqbal A, Hardiman T, Zabinski T, Man F, de Rosales RTM, Xie J, Aswad F, Achkova D, Joseph CR, Ciprut S, Adami A, Roider HG, Hess-Stumpp H, Győrffy B, Quist J, Grigoriadis A, Sommer A, Tutt ANJ, Davies DM, Maher J.Cell Rep Med. 2021 Dec 21;2(12):100473. doi: 10.1016/j.xcrm.2021.100473. eCollection 2021 Dec 21.PMID: 35028614 Free PMC article.
Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors. Muliaditan T, Halim L, Whilding LM, Draper B, Achkova DY, Kausar F, Glover M, Bechman N, Arulappu A, Sanchez J, Flaherty KR, Obajdin J, Grigoriadis K, Antoine P, Larcombe-Young D, Hull CM, Buus R, Gordon P, Grigoriadis A, Davies DM, Schurich A, Maher J.Cell Rep Med. 2021 Dec 21;2(12):100457. doi: 10.1016/j.xcrm.2021.100457. eCollection 2021 Dec 21.PMID: 35028604 Free PMC article.
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group. El Bairi K, Haynes HR, Blackley E, Fineberg S, Shear J, Turner S, de Freitas JR, Sur D, Amendola LC, Gharib M, Kallala A, Arun I, Azmoudeh-Ardalan F, Fujimoto L, Sua LF, Liu SW, Lien HC, Kirtani P, Balancin M, El Attar H, Guleria P, Yang W, Shash E, Chen IC, Bautista V, Do Prado Moura JF, Rapoport BL, Castaneda C, Spengler E, Acosta-Haab G, Frahm I, Sanchez J, Castillo M, Bouchmaa N, Md Zin RR, Shui R, Onyuma T, Yang W, Husain Z, Willard-Gallo K, Coosemans A, Perez EA, Provenzano E, Ericsson PG, Richardet E, Mehrotra R, Sarancone S, Ehinger A, Rimm DL, Bartlett JMS, Viale G, Denkert C, Hida AI, Sotiriou C, Loibl S, Hewitt SM, Badve S, Symmans WF, Kim RS, Pruneri G, Goel S, Francis PA, Inurrigarro G, Yamaguchi R, Garcia-Rivello H, Horlings H, Afqir S, Salgado R, Adams S, Kok M, Dieci MV, Michiels S, Demaria S, Loi S; International Immuno-Oncology Biomarker Working Group.NPJ Breast Cancer. 2021 Dec 1;7(1):150. doi: 10.1038/s41523-021-00346-1.PMID: 34853355 Free PMC article. Review.
Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes In Triple-Negative Breast Cancer. Harris RJ, Cheung A, Ng JCF, Laddach R, Chenoweth AM, Crescioli S, Fittall M, Dominguez Rodriguez D, Roberts J, Levi D, Liu F, Alberts E, Quist J, Santaolalla A, Pinder SE, Gillett C, Hammar N, Irshad S, Van Hemelrijck M, Dunn-Walters DK, Fraternali F, Spicer JF, Lacy KE, Tsoka S, Grigoriadis A, Tutt ANJ, Karagiannis SN.
Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication. Liu F, Hardiman T, Wu K, Quist J, Gazinska P, Ng T, Purushotham A, Salgado R, Guo X, Pinder SE, Grigoriadis A.
Immune Crosstalk Between Lymph Nodes and Breast Carcinomas, With a Focus on B Cells. Elena Alberts, Isobelle Wall, Dinis Pedro Calado, Anita Grigoriadis.
Random Forest Modelling of High-Dimensional Mixed-Type Data for Breast Cancer Classification. Jelmar Quist, Lawson Taylor, Johaan Staaf, Anita Grigoriadis.
Assessment of structural chromosomal instability phenotypes as biomarkers of carboplatin response in triple negative breast cancer: the TNT trial. O Sipos, H Tovey, J Quist, S Haider, S Nowinski, P Gazinska, S Kernaghan, C Toms, S Maguire, N Orr, S C Linn, J Owen, C Gillett, S E Pinder, J M Bliss, A Tutt, M C U Cheang, A Grigoriadis.

2020

Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases. De Piano M, Manuelli V, Zadra G, Otte J, Edqvist PD, Pontén F, Nowinski S, Niaouris A, Grigoriadis A, Loda M, Van Hemelrijck M, Wells CM.
Invasive breast cancer over four decades reveals persisting poor metastatic outcomes in treatment resistant subgroup – the “ATRESS” phenomenon. Jurrius P, Green T, Garmo H, Young M, Cariati M, Gillett C, Mera A, Harries M, Grigoriadis A, Pinder S, Holmberg L, Purushotham A.

2019

An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer. Wu Y, Kyle-Cezar F, Woolf RT, Naceur-Lombardelli C, Owen J, Biswas D, Lorenc A, Vantourout P, Gazinska P, Grigoriadis A, Tutt A, Hayday A.
Metabolic profiles to predict long-term cancer and mortality: the use of latent class analysis. Santaolalla A, Garmo H, Grigoriadis A, Ghuman S, Hammar N, Jungner I, Walldius G, Lambe M, Holmberg L, Van Hemelrijck M.
Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer. Evans R, Flores-Borja F, Nassiri S, Miranda E, Lawler K, Grigoriadis A, Monypenny J, Gillet C, Owen J, Gordon P, Male V, Cheung A, Noor F, Barber P, Marlow R, Francesch-Domenech E, Fruhwirth G, Squadrito M, Vojnovic B, Tutt A, Festy F, De Palma M, Ng T.
Pan-cancer transcriptomic analysis dissects immune and proliferative functions of APOBEC3 cytidine deaminases. Ng JCF, Quist J, Grigoriadis A, Malim MH, Fraternali F

2018

Repurposing tin mesoporphyrin as an immune checkpoint inhibitor shows therapeutic efficacy in preclinical models of cancer. Muliaditan T, Opzoomer J, Caron J, Okesola M, Kosti P, Lall S, Dazzi F, Tutt A, Grigoriadis A, Gillett C, Madden S, Burchell J, Kordasti S, Diebold S, Spicer J, and Arnold J. Clin Cancer Res 2018 Apr 1;24(7):1617-1628. doi: 10.1158/1078- 0432.CCR-17-2587 PMID: 29339440.
A randomised phase III trial of carboplatin compared with docetaxel in BRCA1/2 mutated and pre-specified triple negative breast cancer “BRCAness” subgroups: the TNT Trial. Tutt A, Tovey H, Cheang MCC, Kernaghan S, Kilburn L, Gazinska P, Owen J, Abraham J, Barrett S, Barrett-Lee P, Brown R, Chan S, Dowsett M, Flanagan JM, Fox L, Grigoriadis A, Gutin A, Harper-Wynne C, Hatton MQ, Hoadley KA, Parikh J, Parker P, Perou CM, Roylance R, Shah V, Shaw A, Smith IE, Timms KM, Wardley AM, Wilson G, Gillett C, Lanchbury JS, Ashworth A, Rahman N, Harries M, Ellis P, Pinder SE, Bliss JM, on behalf of the TNT Trialists. Nat Med. 2018 May;24(5):628-637. doi: 10.1038/s41591-018-0009-7. PMID: 29713086.
Anti-Folate Receptor Alpha-Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer. Cheung A, Opzoomer J, Ilieva KM, Gazinska P, Hoffmann RM, Mirza H, Marlow R, Francesch-Domenech E, Fittall M, Dominguez Rodriguez D, Clifford A, Badder L, Patel N, Mele S, Pellizzari G, Bax HJ, Crescioli S, Petranyi G, Larcombe-Young D, Josephs DH, Canevari S, Figini M, Pinder S, Nestle FO, Gillett C, Spicer JF, Grigoriadis A, Tutt ANJ, Karagiannis SN. Clin Cancer Res. 2018 Oct 15;24(20):5098-5111. doi: 10.1158/1078-0432.CCR-18-0652. PMID: 30068707.
Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells. Tornillo G, Knowlson C, Kendrick H, Cooke J, Mirza H, Aurrekoetxea-Rodríguez I, Vivanco MDM, Buckley NE, Grigoriadis A, Smalley MJ.
Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients. Breast Cancer Research 2018 Nov 20;20(1) doi: 10.1186/s13058-018-1070-3. Chatterjee G, Pai T, Hardiman T, Avery-Kiejda K, Scott RJ, Spencer J, Pinder SE, Grigoriadis A
A four-gene decision tree signature classification of triple-negative breast cancer: Implications for targeted therapeutics. Jelmar Quist, Hasan Mirza, Maggie C.U. Cheang, Melinda L Telli, Joyce O’Shaughnessy, Christopher J. Lord, Andrew N. J. Tutt and Anita Grigoriadis
Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer. Nat Commun. 2018 Mar 13;9(1):1044. doi: 10.1038/s41467-018-03283-z. Patel N, Weekes D, Drosopoulos K, Gazinska P, Noel E, Rashid M, Mirza H, Quist J, Brasó-Maristany F, Mathew S, Ferro R, Pereira AM, Prince C, Noor F, Francesch-Domenech E, Marlow R, de Rinaldis E, Grigoriadis A, Linardopoulos S, Marra P, Tutt ANJ.
An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration. BMC Biology 2018 March 6.16:29 doi: 10.1186/s12915-018-0489-4. Tajadura-Ortega V, Garg R, Allen R, Owczarek C, Bright MD, Kean S, Mohd-Noor A, Grigoriadis A, Elston TC, Hahn KM, Ridley AJ.
Systematic identification of functionally relevant risk alleles to stratify aggressive versus indolent prostate cancer. Oncotarget. 2018 Feb 5;9(16):12812-12824. doi: 10.18632/oncotarget.24400 Nowinski S, Santaolalla A, O’Leary B, Loda M, Mirchandani A, Emberton M, Van Hemelrijck M, Grigoriadis A.
Histological scoring of immune and stromal features in breast and axillary lymph nodes is prognostic for distant metastasis in lymph node-positive breast cancers. Journal of Pathology: Clinical Research 2018 January 8. doi: 10.1002/cjp2.87. Grigoriadis A, Patrycja Gazinska P, Trupti Pai T, Irhsad S, Wu Y, Millis R, Naidoo K, Owen J, Gillett CE, Tutt A, Coolen ACC, Pinder SE.

2017

Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer. Mol Cancer Ther. 2018 Jan;17(1):306-315. Epub 2017 Nov 13. doi: 10.1158/1535-7163.MCT-17-0760. (PMID: 29133620) Naidoo K, Wai PT, Maguire SL, Daley F, Haider S, Kriplani D, Campbell J, Mirza H, Grigoriadis A, Tutt A, Moseley PM, Abdel-Fatah TMA, Chan SYT, Madhusudan S, Rhaka EA, Ellis IO, Lord CJ, Yuan Y, Green AR, Natrajan R.
Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study. Breast Cancer Res. 2017 Oct 13;19(1):113. doi: 10.1186/s13058-017-0881-y. (PMID: 29029636) Lawler K, Papouli E, Naceur-Lombardelli C, Mera A, Ougham K, Tutt A, Kimbung S, Hedenfalk I, Zhan J, Zhang H, Buus R, Dowsett M, Ng T, Pinder SE, Parker P, Holmberg L, Gillett CE, Grigoriadis A, Purushotham A.
RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers. Cancer Research. 2017 March 1. doi: 10.1158/0008-5472.CAN-16-0598. Irshad S, Flores-Borja F,Lawler K,3, Monypenny J, Evans R, Male V, Gordon P, Cheung A, Gazinska P, Noor F, Wong F, Grigoriadis A, Fruhwirth GO, Barber PR, Woodman N, Patel D, Rodriguez-Justo M, Owen J, Martin SG, Pinder SE, Gillett CE, Poland SP, Ameer-Beg S, McCaughan F, Carlin LM, Hasan U, Withers DR, Lane P, Vojnovic B, Quezada SA, Ellis P, Tutt AN, Ng T.
Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer. The journal of Pathology. 2017 February. doi: 10.1002/path.4841. Corda G, Sala G, Lattanzio R, Iezzi M, Sallese M, Fragassi G, Lamolinara A, Mirza H, Barcaroli D, Ermler S, Silva E, Yasaei H, Newbold RF, 1 , Vagnarelli P, Mottolese M, 9 Natali PG, Perracchio L, Quist J, Grigoriadis A, Marra P, Tutt AN, 7 , Piantelli M, Iacobelli S, 3 , Laurenzi VD, Sala A.
Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients’ survival. Science Reports. 2017 January 6. doi: 10.1038/srep40177. Gracio F, Burford B, Gazinska P, Mera A, Mohd Noor A, Marra P, Gillett C, Grigoriadis A, Pinder S, Tutt A, de Rinaldis E.
PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression. Breast Cancer Research. 2017 January. doi: 10.1186/s13058-016-0789-y. Shah V, Nowinski S, Levi D, Shinomiya I, Kebaier Ep Chaabouni N, Gillett C, Grigoriadis A, Graham TA, Roylance R, Simpson MA, Pinder SE, Sawyer EJ.

2016

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nature Medicine. 2016 October. doi:10.1038/nm.4198. Maristany FB, Filosto S, Catchpole S, Marlow R, Quist J, Domenech EF, Plumb DA, Zakka L, Gazinska P, Liccardi G, Meier P, Oliver AG, Cheang MCU, Rosell AP, Shafat M, Noël E, Patel N, McEachern K, Scaltriti M, Castel P, Noor F, Buus R, Mathew S, Watkins J, Serra V, Marra P, Grigoriadis A, Tutt AN.
Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium. Oncogene. 2016 October 3. doi: 10.1038/onc.2016.342. Daly C S, Shaw P, Ordonez L D, Williams G T, Quist J, Grigoriadis A, Van Es J H, Clevers H, Clarke A R, Reed K R.
Tandem duplications contribute to not one but two distinct phenotypes, Proc Natl Acad Sci U S A. 2016 Aug 19. pii: 201610228. Watkins J, Tutt A, Grigoriadis A
Targeting folate receptor alpha for cancer treatment. Oncotarget. 2016 May 27. doi: 10.18632/oncotarget.9651. Cheung A, Bax HJ, Josephs DH, Ilieva KM, Pellizzari G, Opzoomer J, Bloomfield J, Fittall M, Grigoriadis A, Figini M, Canevari S, Spicer JF, Tutt AN, Karagiannis SN.
Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B. PLoS One. 2016 May 10;11(5):e0155391. doi: 10.1371/journal.pone.0155391. eCollection 2016 Akre MK, Starrett GJ, Quist JS, Temiz NA, Carpenter MA, Tutt AN, Grigoriadis A, Harris RS.

2015

Big Data: The Challenge for Small Research Groups in the Era of Cancer Genomics, BJC 2015 17; 113(10):1405-12. doi: 10.1038/bjc.2015.341 PMID:26492224. Mohd Noor A, Holmberg L, Gillett C, Grigoriadis A
Selection and evolution in the genomic landscape of copy number alterations in ductal carcinoma in situ (DCIS) and its progression to invasive carcinoma of ductal/no special type – a meta-analysis. Breast Cancer Research Treatment 2015 Aug;153(1):101-21. doi: 10.1007/s10549-015-3509-x. Rane SU, Mirza H, Grigoriadis A, Pinder SE.
Digital imaging in the immunohistochemical evaluation of the proliferation markers Ki67, MCM2 and Geminin, in early breast cancer, and their putative prognostic value. BMC Cancer. 2015 Jul 25;15:546. doi: 10.1186/s12885-015-1531-3. PMID:26205655. Joshi S, Watkins J, Gazinska P, Brown JP, Gillett CE, Grigoriadis A, Pinder SE.
Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms. Mol Oncol. 2015 Mar 20. pii: S1574-7891(15)00051-4. PMID: 25825120. Schouten PC, Grigoriadis A, Kuilman T, Mirza H, Watkins JA, Cooke SA, van Dyk E, Severson TM, Rueda OM, Hoogstraat M, Verhagen CV, Natrajan R, Chin SF, Lips EH, Kruizinga J, Velds A, Nieuwland M, Kerkhoven RM, Krijgsman O, Vens C, Peeper D, Nederlof PM, Caldas C, Tutt AN, Wessels LF, Linn SC.
Profiles of genome complexity identify HORMAD1 as a cause of homologous recombination deficiency in triple-negative breast cancers. Cancer Discov. 2015 Mar 13. pii: CD-14-1092. PMID: 25770156. Watkins JA, Weekes D, Shah V, Gazinska P, Joshi S, Sidhu B, Gillett C, Pinder S, Mayrhofer M, Isaksson A, Cheang MCU, Mirza H, Frankum J, Lord CJ, Ashworth A, Vinayak S, Ford JM, Telli ML, Grigoriadis A, Tutt ANJ.
Mouse mammary stem-cell genes express prognostic markers in triple-negative breast cancer. Breast Cancer Res. 2015 Dec;17(1):539. doi: 10.1186/s13058-015-0539-6. PMID: 25849541. Soady KJ, Kendrick H, Gao Q, Quist J, Tutt A, Zvelebil M, Ordonez LD, Tan D, Isacke CM, Grigoriadis A, Smalley MJ.
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer Mol Oncol. 2015 Jan;9(1):115-27. PMID:25169931. Vollan HK, Rueda OM, Chin SF, Curtis C, Turashvili G, Shah S, Lingjærde OC, Yuan Y, Ng CK, Dunning MJ, Dicks E, Provenzano E, Sammut S, McKinney S, Ellis IO, Pinder S, Purushotham A, Murphy LC, Kristensen VN, METABRIC Group (Grigoriadis A), Brenton JD, Pharoah PD, Børresen-Dale AL, Aparicio S, Caldas C.

2014

Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers. Breast Cancer Res. 2014 Jun 3;16(3):211 PMID: 25093514. Watkins JA, Irshad S, Grigoriadis A, Tutt A
IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched Triple Negative Breast Cancers. Cancer Res. 2014, Sep1; 74(17):4908-21. PMID:24980552. Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle-Cezar F, Watkins J, Rashid M, De Rinaldis E, Hessey S, Gazinska P, Hayday A and Tutt A.
Identification of a gene regulatory network associated with prion replication. EMBO J. 2014 July17; 33(14):1527-47. PMID:24843046. Marbiah MM, Harvey A, West BT, Louzolo A, Banerjee P, Alden J, Grigoriadis A, Hummerich H, Kan H, Cai Y, Bloom GS, Jat P, Collinge J, Klöhn P.
Immunological visibility: posttranscriptional regulation of human NKG2D ligands by the epidermal growth factor receptor pathway. Sci Transl Med. 2014 Apr 9;6(231):231. PMID:24718859. Vantourout P, Willcox C, Turner A, Swanson CM, Haque Y, Sobolev O, Grigoriadis A, Tutt A, Adrian Hayday A.

2013

Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control. BMC Genomics 2013 Sep 14(1):643. PMID: 24059244. de Rinaldis E, Gazinska P, Mera A, Modrusan Z, Fedorowicz GM, Burford B, Gillett C, Marra P, Grigoriadis A, Dornan D, Holmberg L, Pinder S, Tutt A.
Comparison of basal-like triple negative breast cancer defined by morphology, immunohistochemistry and transcriptional profiles. Modern Pathology 2013 Feb 8. doi: 10.1038/modpathol.2012.244. PMID: 23392436.Grigoriadis A, Gazinska P, Brown JP, Millis R, Mera A, Gillett C, Holmberg L, Tutt A, Pinder SE.

2012

Molecular characterisation of cell line models for triple negative breast cancers. BMC Genomics 2012 Nov 14;13(1):619. PMID: 23151021. Grigoriadis A, Mackay A, Noel E, Wu PJ, Natrajan R, Frankum J, Reis-Filho JS, Tutt A.
Profiling the immune stromal interface in breast cancer and its potential for clinical impact. Breast Cancer Care 2012;7:273–280. PMID:23904829. Irshad S, Grigoriadis A, Lawler K, Ng T and Tutt A.
Prognostic signatures in breast cancer: correlation does not imply causation. Breast Cancer Res. 2012 Jun 19;14(3):313. PMID:22713235.Ng C, Weigelt B, Grigoriadis A, Reis-Filho JS.
The Genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. 2012 Apr 18; 486(7403):346-52. PMID:22522925. Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, Gräf S, Ha G, Haffari G, Bashashati A, Russell R, McKinney S; METABRIC Group (Grigoriadis A), Langerød A, Green A, Provenzano E, Wishart G, Pinder S, Watson P, Markowetz F, Murphy L, Ellis I, Purushotham A, Børresen-Dale AL, Brenton JD, Tavaré S, Caldas C, Aparicio S.
A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and-positive breast cancers. J Pathol. 2012 Feb 23. 227(1):29-41. PMID: 22362584. Natrajan R, Mackay A, Lambros MB, Weigelt B, Wilkerson PM, Manie E, Grigoriadis A, A’hern R, van der Groep P, Kozarewa I, Popova T, Mariani O, Turaljic S, Furney SJ, Marais R, Rodruigues DN, Flora AC, Wai P, Pawar V, McDade S, Carroll J, Stoppa-Lyonnet D, Green AR, Ellis IO, Swanton C, van Diest P, Delattre O, Lord CJ, Foulkes WD, Vincent-Salomon A, Ashworth A, Henri Stern M, Reis-Filho JS.

2011

Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers. Cancer Res. 2011 Dec 15;71(24):7683-93. PMID:22025563. Julien S, Ivetic A, Grigoriadis A, Qize D, Burford B, Sproviero D, Picco G, Gillett C, Papp SL, Schaffer L, Tutt A, Taylor-Papadimitriou J, Pinder SE, Burchell JM.
DART: Denoising Algorithm based on Relevance network Topology improves molecular pathway activity inference. BMC Bioinformatics. 2011 Oct 19;12:403. PMID:22011170. Jiao Y, Lawler K, Patel GS, Purushotham A, Jones AF, Grigoriadis A, Tutt A, Ng T, Teschendorff AE
The ForeSee (4C) Approach for Integrative Analysis in Gene Discovery. Methods Mol Biol. 2011;760:53-71. PMID:21779990. Yike Guo, Robin EJ Munro, Kalaitzopoulos D, Grigoriadis A
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J Pathol. 2011 Jul;224(3):334-43. PMID:21598255. Amary MF, Bacsi K, Maggiani F, Damato S, Halai D, Berisha F, Pollock R, O’Donnell P, Grigoriadis A, Diss T, Eskandarpour M, Presneau N, Hogendoorn PC, Futreal A, Tirabosco R, Flanagan AM.
Microarray-Based Class Discovery for Molecular Classification of Breast Cancer: Analysis of Interobserver Agreement. J Natl Cancer Inst. 2011 Apr 20;103(8):662-73. PMID:21421860. Mackay A, Weigelt B, Grigoriadis A, Kreike B, Natrajan R, A’hern R, Tan DS, Dowsett M, Ashworth A, Reis-Filho JS.

2010

G_D3 synthase expression enhances proliferation and tumour growth of MDA-MB-231 breast cancer cells through c-MET activation. Molecular Cancer Research. 2010 Nov; 8 (110):1526-35. PMID: 20889649. Cazet A, Lefebvr J, Adriaenssens E, Julie S, Bobowski M, Grigoriadis A, Tutt A, Tulasne D, Le Bourhis XF, Delannoy P.
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell. 2010 Sep 3; 7(3);403-17. PMID:20804975. Molyneux G, Geyer FC, Magnav FA, McCarthy A, Kendrick H, Natrajan R, Mackay A, Grigoriadis A, Tutt A, Ashworth A, Reis-Filho JS, Smalley MJ.
Genomic distance entrained clustering and regression modelling highlights interacting genomic regions contributing to proliferation in breast cancer. BMC System Biol. 2010 Sep 8; 4(1):127. PMID:20825665. Dexter TJ, Sims D, Mitsopoulos C, Mackay A, Grigoriadis A, Ahmad AS, Zvelebil M
Comparative Membranome expression analysis in primary tumours and derived cell lines. PLos One. 2010 Jul23; 5(7):e11742. PMID:20668533. Uva P, Lahm A, Sbardellati A, Grigoriadis A, Tutt A, de Rinalidis E
Transcriptomic analysis of tubular carcinomas of the breast reveals similarties and differences with molecular subtype-matched ductual and lobular carcinomas. J Pathol. 2010 Sep; 222(1):64-75. PMID:20593406. Lopez-Garcia MA, Geyer FC, Natrajan R, Kreike B, Mackay A, Grigoriadis A, Reis-Filho JS, Weigelt B.
A Distinct Spectrum of Copy Number Aberrations in Pediatric High-Grade Gliomas. Clin Cancer Res. 2010 Jul 1;16(13):3368-77. PMID: 20570930. Bax DA, Mackay A, Little SE, Carvalho D, Viana-Pereira M, Tamber N, Grigoriadis A, Ashworth A, Reis RM, Ellison DW, Al-Sarraj S, Hargrave D, Jones C.
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res. 2010 Mar 1;70(5):2085-94. PMID: 20179196. Turner N, Pearson A, Sharpe R, Lambros M, Geyer F, Lopez-Garcia MA, Natrajan R, Marchio C, Iorns E, Mackay A, Gillett C, Grigoriadis A, Tutt A, Reis-Filho JS, Ashworth A.
An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers. Breast Cancer Res Treat. 2010 Jun;121(3):575-89. PMID:19688261. Natrajan R, Weigelt B, Mackay A, Geyer FC, Grigoriadis A, Tan DS, Jones C, Lord CJ, Vatcheva R, Rodriguez-Pinilla SM, Palacios J, Ashworth A, Reis-Filho JS.

2009

CT-X antigen expression in human breast cancer. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13493-8.PMID:19651608. Grigoriadis A, Caballero OL, Hoek KS, da Silva L, Chen YT, Shin SJ, Jungbluth A, Miller LD, Clouston D, Cebon J, Old L, Lakhani S, Simpson AJG, Munro Neville AM.
Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues. BMC Genomics. 2009 Jul 17;10:324. PMID:19615061. Grigoriadis A, Oliver GR, Tanney A, Kendrick H, Smalley M, Jat PS, Neville AM.
Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation. J Pathol. 2009 Nov;219(3):306-16. PMID:19681070. McCarthy A, Lord C, Savage K, Grigoriadis A, Smith DS, Weigelt B, Reis-Filho JS, Ashworth A.
Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation.. J Pathol. 2009 Sep;219(1):131-40. PMID:19562735. Westbury CB, Reis-Filho JS, Dexter T_,Mahler-Araujo B, Fenwick K, Iravani M, Grigoriadis A, Parry S, Robertson D, Mackay A, Ashworth A, Yarnold J, Isacke CM.
Tiling path genomic profiling of grade 3 invasive ductal breast cancers. Clin Cancer Res. 2009 Apr 15;15(8):2711-22. PMID:19318498. Natrajan R, Lambros MB, Rodríguez-Pinilla SM, Moreno-Bueno G, Tan DS, Marchió C, Vatcheva R, Rayter S, Mahler-Araujo B, Fulford LG, Hungermann D, Mackay A, Grigoriadis A, Fenwick K, Tamber N, Hardisson D, Tutt A, Palacios J, Lord CJ, Buerger H, Ashworth A, Reis-Filho JS.
Integrated functional, gene expression and genomic analysis for the identification of cancer targets. PLoS ONE. 2009;4(4):e5120. 9. PMID:19357772. Iorns E, Lord CJ, Grigoriadis A, Mcdonald S, Fenwick K, Mackay A, Mein CA, Natrajan R, Savage K, Tamber N, Reis-filho JC, Turner NC, Ashworth A.
Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development. PLoS ONE. 2009;4(4):e5209. PMID:19365568. Bax DA, Little SE, Gaspar N, Perryman L, Marshall L, Viana-Pereira M, Jones TA, Williams RD, Grigoriadis A, Vassal G, Workman P, Sheer D, Reis RM, Pearson AD, Hargrave D, Jones C.
A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines. Breast Cancer Res Treat. 2009 Dec;118(3):481-98. PMID:19169812. Mackay A, Tamber N, Fenwick K, Iravani M, Grigoriadis A, Dexter T, Lord CJ, Reis-Filho JS, Ashworth A

2008

Perilobar nephrogenic rests are nonobligate molecular genetic precursor lesions of insulin-like growth factor-II-associated Wilms tumors. Clin Cancer Res. 2008 Dec 1;14(23):7635-44. PMID:19047088. Vounonvirta R, Sebire NJ, Dallosso AR, Reis-Filho JS, Williams RD, Mackay A, Fenwick K, Grigoriadis A, Ashworth A, Pritchard-Jones K, Brown KW, Vujanic GM, Jones C.
Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. BMC Genomics. 2008 Dec 8;9:591. PMID:19063729. Kendrick H, Regan JL, Magnay FA, Grigoriadis A, Mitsopoulos C, Zvelebil M, Smalley MJ.

2007

ET-1 promotes desmoplasia in human colorectal fibroblasts. Loizidou M, Hoosein M, Knowles J, Xu S, Grigoriadis A, Dashwood M, Abraham D, Taylor I. European Journal of Surgical Oncology. 33(9): 1105. 2007.
Regulator of G-protein signalling 2 (RGS2) mRNA is differentially expressed in mammary epithelial subpopulations and overexpressed in the majority of breast cancers. Breast Cancer Res. 2007 Dec 8;9(6):R85. PMID:18067675. Smalley MJ , Iravani M, Leao M, Grigoriadis A, Kendrick H, Dexter T, Fenwick K, Regan J, Britt K, McDonald S, Lord CJ, MacKay A, Ashworth A.
Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH. Genes Chromosomes Cancer. 2007 Jun; 46(6):607-15. PMID: 17370329. Natrajan R, Williams RD, Grigoriadis A, Mackay A, Fenwick K, Ashworth A, Dome JS, Grundy PE, Pritchard-Jones K, Jones C.

2006

Establishment of the epithelial–specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data. Breast Cancer Res. 2006; 8(5):R56. PMID:17014703. Grigoriadis A, Mackay A, Reis-Filho JS, Steele D, Isel C, Stevenson BJ, Jongeneel CV, Valgeirsson H, Fenwick K, Iravani M, M. Leao, Simpson AJG, Strausberg RL, Jat PS, Ashworth A, Neville AM, O’Hare MJ.
FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas. Clin Cancer Res. 2006 Nov 15; 12(22):6652-62. PMID:17121884. Reis-Filho JS, Simpson PT, Turner NC, Lambros M, Jones C, Mackay A, Grigoriadis A, Sarrio D, Savage K, Steele D, Dexter T, Iravani M, Fenwick K, Weber B, Hardisson D, Schmitt FC, Palacios J, Lakhani SR, Ashworth A.
Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse. J Pathol. 2006 Sep; 210(1):49-58. PMID:16823893. Natrajan R, Williams RD, Hing SN, Mackay A, Reis-Filho JS, Fenwick K, Iravani M, Valgeirsson H, Grigoriadis A, Langford CF, Dovey O, Gregory SG, Weber BL, Ashworth A, Grundy PE, Pritchard-Jones K, Jones C.

Earlier

Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer. Jones C, Mackay A, Grigoriadis A, Cossu A, Reis-Filho JS, Fulford L, Dexter T, Davies S, Bulmer K, Ford E, Parry S, Budroni M, Palmieri G, Neville AM, O’Hare MJ, Lakhani SR. Cancer Res. 2004 64: 3037-3045. PMID: 15126339.
Cloning and characterization of CpG islands of the human chromosome 1p36 region. Ellmeier W, Barnas C, Kobrna A (maiden name), Kleiner E, Kurzbauer R and Weith A. Genomics. 1996 32:155-158. PMID: 8786109.
Rat embryo fibroblasts immortalized with simian virus 40 large T antigen undergo senescence upon its inactivation. Gonos ES, Burns JS, Mazars GR, Kobrna A (maiden name), Riley TE, Barnett SC, Zafarana G, Ludwig RL, Ikram Z, Powell AJ and Jat PS. Mol. Cell Biol.1996. 16:5127-5138. PMID: 8756670.